Clinical comparison · Growth hormone
CJC-1295 vs Sermorelin
Both are GHRH analogs. CJC-1295 (especially with DAC) has a longer half-life; sermorelin has the longer clinical track record and lower cost.
Attribute
CJC-1295
Sermorelin
Mechanism
GHRH analog; DAC variant binds albumin for ~8-day half-life.
Truncated GHRH (1-29) analog. Restores endogenous pulsatile GH secretion.
Standard dosing
100 mcg with ipamorelin 1–3x daily (no DAC), or 1–2 mg weekly (with DAC).
200–500 mcg SC nightly, often cycled 5-on/2-off.
Indications
- Longevity
- Body composition
- Recovery adjunct
- Adult GH decline
- Sleep quality
- Body composition
Strengths
- Longer half-life than sermorelin (with DAC)
- Synergy with ipamorelin
- Longest clinical track record among GHRHs
- Entry-level cost
Cautions
- Blunted pulsatility with DAC variant
- Monitor fasting glucose
- Shorter half-life than CJC-1295
- May affect glucose tolerance
Choose CJC-1295 when
Patient wants weekly dosing (with DAC) or a modernized GHRH paired with ipamorelin (no DAC).
Wholesale CJC-1295 →Choose Sermorelin when
Patient wants an established, entry-level GHRH for nightly use.
Wholesale Sermorelin →FAQs
- Should I use CJC-1295 with or without DAC?
- Without DAC for pulsatile stacking with ipamorelin. With DAC for weekly, sustained GHRH exposure.
- Is CJC-1295 stronger than sermorelin?
- Half-life is longer with CJC-1295 (DAC). Peak GH pulse per dose is similar; the difference is dosing frequency.