Clinical reference
Peptide-vs-peptide comparisons
Head-to-head clinical comparisons of the peptides clinicians prescribe most. Mechanism, dosing, indications, side effects, and selection criteria.
GLP-1 / weight loss
Semaglutide vs Tirzepatide
Semaglutide is the entry-level GLP-1 with a longer clinical history and lower cost. Tirzepatide is the dual GIP/GLP-1 successor with superior weight-loss outcomes in head-to-head trials.
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Recovery
BPC-157 vs TB-500
BPC-157 and TB-500 are the two most-requested recovery peptides. BPC-157 shines for local injury and GI protocols; TB-500 covers systemic soft-tissue healing.
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Growth hormone
Ipamorelin vs Sermorelin
Ipamorelin is a selective GHRP; sermorelin is a GHRH. They act on different receptors, so the real question is which class fits your patient — or whether to stack both.
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Growth hormone
CJC-1295 vs Sermorelin
Both are GHRH analogs. CJC-1295 (especially with DAC) has a longer half-life; sermorelin has the longer clinical track record and lower cost.
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Growth hormone
Tesamorelin vs Sermorelin
Both are GHRH analogs, but tesamorelin has the strongest evidence for visceral fat reduction and an FDA-approved indication.
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Growth hormone
Ipamorelin vs CJC-1295
This isn't really vs — it's the canonical GHRP + GHRH stack. Comparing side by side helps clarify which one is doing what work in a combined protocol.
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GLP-1 / weight loss
Tirzepatide vs Retatrutide
Tirzepatide is the current best-in-class dual agonist. Retatrutide is the triple agonist behind it in the pipeline with larger phase-2 weight-loss numbers.
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Weight loss
Semaglutide vs AOD-9604
Semaglutide is the anchor GLP-1. AOD-9604 is a fat-mobilizing hGH fragment used as an adjunct, not a replacement.
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Weight loss
Semaglutide vs 5-Amino-1MQ
Semaglutide is a GLP-1 injectable. 5-Amino-1MQ is an oral NNMT inhibitor that restores adipocyte NAD+ metabolism.
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Sexual wellness
PT-141 vs Oxytocin
PT-141 is a melanocortin agonist acting on arousal circuits. Oxytocin supports bonding and intimacy but is not a primary libido agent.
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IV / longevity
NAD+ vs Glutathione
NAD+ replenishes the coenzyme central to mitochondrial energy production. Glutathione is the master intracellular antioxidant. Different mechanisms, both anchors of modern IV menus.
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Longevity / immune
Epitalon vs Thymosin Alpha-1
Epitalon is a short-cycle longevity peptide with pineal/telomerase modulation. Thymosin Alpha-1 is an immunomodulator with the strongest clinical support for immune resilience.
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Cognitive / neuro
Selank vs Semax
Both are Russian-origin intranasal neuropeptides. Selank is the anxiolytic; Semax is the focus/BDNF driver.
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Regenerative / aesthetic
GHK-Cu vs BPC-157
GHK-Cu is a copper-binding tripeptide for skin, hair, and dermal remodeling. BPC-157 is a soft-tissue and GI healing peptide.
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Men's health / fertility
Kisspeptin vs hCG
hCG is the long-standing LH mimic for TRT co-therapy and fertility. Kisspeptin is the upstream hypothalamic driver that pulses GnRH to restart the full HPG axis.
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Growth hormone
Hexarelin vs GHRP-6
Both are early-generation GHRPs. Hexarelin has stronger per-dose GH release; GHRP-6 has the strongest appetite stimulation.
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Metabolic
MOTS-c vs 5-Amino-1MQ
MOTS-c is an injected mitochondrial peptide activating AMPK. 5-Amino-1MQ is an oral small molecule restoring adipocyte NAD+ metabolism.
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Sleep / longevity
DSIP vs Epitalon
DSIP directly modulates slow-wave sleep. Epitalon is a cycled longevity peptide with secondary circadian/pineal effects.
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Sexual wellness
Melanotan II vs PT-141
Melanotan II is the non-selective melanocortin agonist (tanning + libido). PT-141 is the MC3/MC4-selective variant developed specifically for sexual function.
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Gut / anti-inflammatory
KPV vs BPC-157
KPV is an alpha-MSH-derived anti-inflammatory tripeptide. BPC-157 is the general soft-tissue and GI healing peptide.
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Cognitive / neuro
Cerebrolysin vs Semax
Cerebrolysin is a neurotrophic peptide mixture with decades of international stroke/TBI use. Semax is an intranasal BDNF-upregulating focus peptide.
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