Clinical comparison · Men's health / fertility
Kisspeptin vs hCG
hCG is the long-standing LH mimic for TRT co-therapy and fertility. Kisspeptin is the upstream hypothalamic driver that pulses GnRH to restart the full HPG axis.
Attribute
Kisspeptin
hCG
Mechanism
Hypothalamic peptide; stimulates GnRH release, driving downstream LH/FSH pulsatility.
Glycoprotein hormone; mimics LH to stimulate testicular Leydig cells and preserve testicular volume on TRT.
Standard dosing
50–200 mcg SC 2–3x weekly (protocol-dependent).
250–500 IU SC 2–3x weekly alongside TRT.
Indications
- HPG axis restart
- Fertility support
- Libido in men
- Testicular preservation on TRT
- Fertility support
- HPG axis maintenance
Strengths
- Upstream endogenous stimulation
- Alternative to hCG for HPG restart
- Long clinical track record
- Directly preserves testicular function
Cautions
- Emerging clinical use
- Requires baseline hormone panel
- Requires refrigeration once reconstituted
- Estradiol rise possible
Choose Kisspeptin when
Patient needs upstream HPG restart or a full endogenous cascade activation.
Wholesale Kisspeptin →Choose hCG when
Patient on TRT needing testicular preservation or a proven fertility protocol.
Wholesale hCG →FAQs
- Does kisspeptin replace hCG?
- Not yet. hCG remains the standard on-TRT co-therapy. Kisspeptin is emerging for HPG restart protocols.
- Can they be combined?
- Rarely in the same phase. Kisspeptin for restart, hCG for ongoing testicular preservation once TRT resumes.