Clinical comparison · Sexual wellness
Melanotan II vs PT-141
Melanotan II is the non-selective melanocortin agonist (tanning + libido). PT-141 is the MC3/MC4-selective variant developed specifically for sexual function.
Attribute
Melanotan II
PT-141
Mechanism
Non-selective melanocortin agonist (MC1/MC3/MC4); pigmentation plus libido effects.
Melanocortin MC3/MC4 receptor agonist acting centrally on sexual arousal pathways.
Standard dosing
0.25–1 mg SC as needed with sun exposure protocols.
1–2 mg SC 45 minutes before activity, max 8 doses/month.
Indications
- Tanning response
- Libido adjunct
- HSDD in women
- Erectile response adjunct in men
- Libido
Strengths
- Dual pigmentation + libido effect
- Central mechanism independent of vascular pathway
- Works when PDE5 inhibitors fail
Cautions
- Nausea, moles darkening, blood-pressure effects
- Not for melanoma-risk patients
- Nausea, flushing
- Transient blood-pressure increase
- Avoid in uncontrolled hypertension
Choose Melanotan II when
Patient wants pigmentation response and accepts the systemic side-effect profile.
Wholesale Melanotan II →FAQs
- Is Melanotan II used clinically for libido?
- Rarely — PT-141 is the clinical-grade choice. Melanotan II sits primarily in aesthetic/tanning protocols.
- Do these darken moles?
- Melanotan II can. Screen skin lesions before use and photo-document baseline.