Clinical comparison · Growth hormone
Tesamorelin vs Sermorelin
Both are GHRH analogs, but tesamorelin has the strongest evidence for visceral fat reduction and an FDA-approved indication.
Attribute
Tesamorelin
Sermorelin
Mechanism
GHRH analog with sustained action, FDA-approved for HIV-associated lipodystrophy.
Truncated GHRH (1-29) analog. Restores endogenous pulsatile GH secretion.
Standard dosing
2 mg SC daily for 6–12 months.
200–500 mcg SC nightly, often cycled 5-on/2-off.
Indications
- Visceral adiposity
- HIV lipodystrophy
- Body composition
- Adult GH decline
- Sleep quality
- Body composition
Strengths
- Strongest evidence for visceral fat reduction
- FDA-approved indication
- Longest clinical track record among GHRHs
- Entry-level cost
Cautions
- Daily dosing
- Higher cost
- Injection-site reactions
- Shorter half-life than CJC-1295
- May affect glucose tolerance
Choose Tesamorelin when
Patient's goal is visceral adiposity reduction or metabolic syndrome improvement.
Wholesale Tesamorelin →Choose Sermorelin when
Patient wants a general anti-aging GHRH at entry-level cost.
Wholesale Sermorelin →FAQs
- Why is tesamorelin more expensive?
- It carries an FDA-approved indication and requires daily dosing at a higher mg per injection than sermorelin.
- Can tesamorelin be paired with ipamorelin?
- Short-term stacking is used clinically; long-term monotherapy is more common due to cost.